With 8 days you should just do Salta. I know that is not what you want to hear. There are enough beautiful/mind-blowing/incredible/once in a life time things to see just there alone. Don't bother trying to get to Uyuni and/or San Pedro, it will take anywhere between 10-24 hours depending on which one and how you go, and you will need time to rest after the travel. The bus from San Pedro to Salta is 10 hours during the daytime, so that's a day wasted. San Pedro is the most expensive of the 3 regions.
If you must insist on seeing more than just Salta in 8 days (and I guarantee that at the end of it you will decide that you must go back to Salta for more later- as I did!) then you should do San Pedro as it's closer and more comfortable than entering Bolivia and going all the way to Uyuni for a more 'rugged' (and exhausting) tour. That's not to say you shouldn't go to Uyuni at a later time!! But in San Pedro you need 2.5-3 full days minimum as well not including travel times. There is the Valley of the Moon half-day tour, the full day lagoons/salares tour, and the early morning geysers tour (which I wouldn't recommend but it's some people's 'favorite') .
I still recommend just doing Salta for now and then go to San Pedro + Bolivia on another trip. If you don't do it this way, you will just have to see what I mean when you go. You will decide that it wasn't enough time and that you have to go back anyway.
Salta is AMAAAAAAAAZING... 4 main circuits plus much more:
1. Altiplano + Salina Grande (salt flat of Argentina and more; amazing but if you can't do them all, this is OK to miss)
2. Quebrada de Humahuaca (don't miss this)
3. Drive to and town of Cachi (don't miss this)
4. Quebrada de Cafayate (don't miss this)
others which I have never done but I heard are great : Molinos and Iruya
Plus you need a day or two in the city of Salta (mummy museum and the lift up the hill) and some days to rest in between the 12-14 hour day tours.
Any more questions just ask!!!
Thanks, this is great. As awesome as Salta sounds, I don't think my friend and I want to stay 8 days in the same place, knowing us. My other friend went recently to Salta and said 2 full days is enough to do the town of Salta, Humahuaca, and Cachi. It seems Humahuaca is on the way to Bolivia, too.
I consider Salta the starting point so we were looking at flights there, but if we wanted to just do San Pedro / Salar de Uyuni, how would we do that? Would we fly into Salta, or La Paz, or how would it work? San Pedro is especially interesting to me because of the potential flower bloom. Bolivia is interesting to me because all of my friends who have been have called it their favorite South American destination, and although I've already been to Chile (central), I do want to see Bolivia. What do you think?