We've lived in
Colegiales for nearly a year now, and love it. It's a real neighborhood, with a nice balance of quiet residential streets and main avenues containing all the amenities and shops you'd ever need. We're super close to the D Line (often remarked to be the best subway line in the city), and can get downtown or to any of the popular neighborhoods within 20-30 minutes. Lots of good bus lines too. Parks and lakes are a quick jog away.
Palermo Hollywood is within walking distance, so we can easily go to all those trendy restaurants without living amongst the glitterati. [If you're into that scene, that's great - but having experienced living in Soho NYC, I'd rather live in Brooklyn. Less fake, more real.] Besides, the grocery prices here in Colegiales are literally 20% cheaper than they are in Palermo.
A comprehensive
study done two years ago found it to have the highest quality of life out of all the neighborhoods in BA.
Like many foreigners, we started out in San Telmo. As much as I love the architecture, very few "real" people live there (uh-oh.. here come the comments!) What I mean is, the streets are deserted on weekends (except for the feria on Defensa which is fun for a while, but becomes simply annoying when you're trying to get through the crowds to your building). There's a definite lack of services for residents living there - no large grocery stores, few pharmacies, etc.
I'd like to try living in Abasto or somewhere a bit more working-class, but for now we're happy in middle-class Colegiales.