COVID-19 vaccine development pipeline gears up

[garryl]

mRNA vaccines need to be stored at -70C and it is a big logistical problem even in the USA.

mRNA vaccines need to be stored at -70C, it's not a problem at all now. Pfizer already made the pizza box to go with it.
It has a GPS and temp tracking. Every box is monitored.
There is only a very small problem, each small set comes in 5, so they have to unfrozen 5 each time, and line up
5 people. That's really not a big deal. Moderna does not need -70c.

 

[garryl]

It's good to have an oximeter with you. It can save your life. When you are infected and blood oxygen is low, you do not know.
You probably just feel tired. May people died in China in March. They walked to hospitals and fell on ground, no one knew they needed
oxygen. You can get one online or have your friend send you one from US, maybe you can find it in Argentine stores.

 

[lunar]

mRNA is much harder to do, Chinese and Russians just do not have resources(tech and fund and time and talent) to do it. Two American(German)
companies happen to be working on that for years.

You send any sequence to China, you get DNA, RNA, mRNA - whatever, back in a few days. This is how USA researchers have done it for years now. Filling some online forms is the only talent required. Cellphones is not the only thing that is made in China, almost all the biotech production is in there.

 

[garryl]

You send any sequence to China, you get DNA, RNA, mRNA - whatever, back in a few days. This is how USA researchers have done it for years now. Filling some online forms is the only talent required. Cellphones is not the only thing that is made in China, almost all the biotech production is in there.

That does not change anything about the Chinese vaccines.
Actually some Chinese experts recommend that Chinese gov not to promote Chinese vaccine,
they are worried that if it does not work or has side effect, it would hurt China's image (which is already bad after COVID).

China Gives Unproven Covid-19 Vaccines to Thousands, With Risks Unknown - The New York Times (nytimes.com)

Vaccine scandal and confidence crisis in China - The Lancet

 

[garryl]

Vaccine Unproven? No Problem in China, Where People Scramble for Shots (Published 2020)

Many say they are reassured because politicians and executives have been inoculated. But experts say the risks outweigh the benefits.

www.nytimes.com

 

[gracielle]

The Moderna Vaccine’s Antibodies May Not Last As Long As We Hoped

The long-term efficacy of Moderna’s mRNA-1273 vaccine, specifically the neutralizing antibody count, may be less than we were hoping for.

www.forbes.com

 

[antipodean]

En Moscú, hasta los médicos desconfían de la Sputnik V: comienzan a arrojar a la basura dosis que se descongelaron y ya no pueden usarse

Una investigación expone las dudas que el proyecto del centro Gamaleya despierta entre el personal de salud. Los 70 centros de vacunación que se abrieron en la capital se encuentran vacíos

www.infobae.com

Not only has one of the key young scientists behind the Russian vaccine been found dead after “falling out a window”, now there are increasing reports coming out of Russia that neither doctors or the people trust the virus, leading them to throw large quantities of the vaccines in the bin because they were not used in time.

Anecdotally, many of the Russians I know and am in contact with tell me that no one of them or their families will take the Russian vaccine because they simply don’t trust it (lack of transparency)

Way to go Argentina. This government sure knows how to spend the money it doesn’t have!

 

[artisans]

From CNN 6 hours ago (now 21:17 on 12/23/20) :
The official Sputnik V Twitter account as well as a statement from the Russian Direct Investment Fund (RDIF-Russia's sovereign wealth fund) announced Wednesday that Argentina is the first country in Latin American to officially register the Covid-19 vaccine.

"Argentina was the first country in Latin America to officially register Sputnik V. The vaccine was registered under the emergency use authorization procedure and was approved by the regulator, ANMAT, based on the results of Phase III clinical trials in Russia, without additional trials in Argentina," the RDIF statement said.

"The registration confirms high confidence in Russian regulatory standards and Sputnik V," the Sputnik V tweet said.
Argentina Health Minister Gines González García tweeted Wednesday that an Aerolineas flight has arrived in Moscow and will bring back 300,000 of the first doses of Russia's Sputnik V vaccine.
"With its arrival in the country, a logistics never before carried out will begin, for a federal and equitable distribution with each of the Argentine provinces," he tweeted.

 

[garryl]

From CNN 6 hours ago (now 21:17 on 12/23/20) :
The official Sputnik V Twitter account as well as a statement from the Russian Direct Investment Fund (RDIF-Russia's sovereign wealth fund) announced Wednesday that Argentina is the first country in Latin American to officially register the Covid-19 vaccine.

"The registration confirms high confidence in Russian regulatory standards and Sputnik V," the Sputnik V tweet said.
Argentina Health Minister Gines González García tweeted Wednesday that an Aerolineas flight has arrived in Moscow and will bring back 300,000 of the first doses of Russia's Sputnik V vaccine.
"With its arrival in the country, a logistics never before carried out will begin, for a federal and equitable distribution with each of the Argentine provinces," he tweeted.

The key word is ' first country'. It's perfect to ride a Chinese train or even a Russian plane. But vaccine, is not the same situation.

 

[artisans]

La Nacion 12/23/20 The KEY WORDS are "who authorizes the emergency use is the portfolio commanded by Ginés González García, who signed Resolution 2784/2020 this noon. Among the considerations of the text, Health wrote: "That the National Administration of Medicines, Food and Medical Technology has intervened within the framework of its powers recommending the authorization of the Sputnik V vaccine. Gamaleya Institute in the Russian Federation, who is the developer of the Sputnik V vaccine, responsible for quality construction and responsible for releasing the processed batches and also, as part of the scheduled visits, has attended the Generium and Biocad plants, among others, that are part of its production process as well as its certification in the country of origin and compliance with quality standards; and has accessed information on its safety and efficacy greater than 91%, as well as that indicating that there have been no serious adverse events, nor have significant differences been identified in the efficacy observed in the different age groups that participated in the trials clinical ".