I don't know the effects, and I don't believe you do either
That means they are likely to be insignificant.
We are basically making significant and permanent changes to the genetic makeup of our food supply ...
We've been doind the same thing by selection for ages. It just happens faster nowadays and gives better results. Does FDA do any testing of varieties of corn, obtained by selection? As to "genetic makeup of our food supply", genetic difference between corn and chicken is much bigger than between regular corn and GMO corn and it does not seem to upset anybody.
I would consider the right to grow food, gather seeds, etc, a part of our natural heritage as human beings.
I consider the right to purchase the software outright to be fundamental, but somehow Adobe thinks that you can only license the Photoshop now. My point is that if you don't like their pricing approach, it does not make them criminal.