Covid Vaccination Argentina

[camberiu]

Brazil is producing SinoVac and has a genocidal nutcase president, it looks awful there.

Brazil is producing Coronovac DESPITE Bolsonaro, not because of him. The entire development and manufacturing of the vaccine in Brazil was sponsored by Doria, the governor of the state Sao Paulo and a staunch Bolsonaro opponent. It was developed and it is being manufactured by the Butantan Institute, an institution that belongs to the State of Sao Paulo. Bolsonaro did everything he could to sabotage and hamper the development of the vaccine.He would publicly mock and rodicule the vaccine call it "vachina" and saying that he would not take it.
The fact that Brazil as of today has administered 27 million doses of Vaccine (Number 5 globally in absolute numbers, behind US, China, India and the UK) is thanks to Doria.

 

[Alby]

China admitió que la eficacia de sus vacunas contra el COVID-19 no es alta

El director de los Centros de Control de Enfermedades, Gao Fu, reveló que las autoridades están considerando distintas opciones como modificar los intervalos de aplicación e incluso nuevas tecnologías para buscar elevar la inmunización

www.infobae.com

It appears even the Chinese government are now critical of Sinopharm and Sinovac.

Given the issues around keeping up with mutations etc, we may be lucky that new drugs for treatment of COVID are in phase 3 testing. Perhaps at the end of the day it won’t be vaccines alone that end the pandemic but tamiflu-style remedies to minimize deaths and serious cases?

If China is telling the truth that it has no coronavirus within its borders, then its conclusions about the effectiveness of its vaccine can only come from the studies it has been undertaking in guinea pig countries, in Latin America and elsewhere. If it wants to try new configurations now, presumably the only way it can do so will be to convince those countries, 12 months into their pandemics, to start new clinical trials. This, in turn, will mean those guinea pig governments will have to admit to their citizenry that the vaccines they have been trumpeting and administering do not work. That seems to be a problem, for those governments, and for the Chinese.

If it is true that there is no virus in China, and China continues to have a zero-tolerance for virus cases, and if the homegrown vaccine for its own population is sub-standard, it can go about vaccinating its 1.2 billion people until the cows come home, but will still be unable to open its borders. Several other countries are going to realize they are in that same situation as the the months and years roll on. But those countries at least have the prospect of eventually accessing the better vaccines, and their economies are insignificant in the world. The prospect of China permanently shut to the world is an interesting one.

 

[lunar]

If China is telling the truth that it has no coronavirus within its borders, then its conclusions about the effectiveness of its vaccine can only come from the studies it has been undertaking in guinea pig countries, in Latin America and elsewhere.

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial - PubMed

Chinese National Key Research and Development Program and Beijing Science and Technology Program.

pubmed.ncbi.nlm.nih.gov

We did a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial of CoronaVac in healthy adults aged 60 years and older in Renqiu (Hebei, China).

Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD-based protein subunit vaccine (ZF2001) against COVID-19 in adults: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials - PubMed

For the Chinese translation of the abstract see Supplementary Materials section.

pubmed.ncbi.nlm.nih.gov

We did two randomised, double-blind, placebo-controlled, phase 1 and phase 2 trials. Phase 1 was done at two university hospitals in Chongqing and Beijing, China, and phase 2 was done at the Hunan Provincial Center for Disease Control and Prevention in Xiangtan, China.

They were hit first. Making an inactivated virus vaccine was the safest bet that delivered results right away. Now they are considering other options.

 

[lunar]

... prospect of eventually accessing the better vaccines ...

After initial mRNA vaccines hype, now there is a shift to Johnson & Johnson adenovirus-based vaccine. Just because it is much cheaper. So, efficacy is not the only key term in this game.

 

[Alby]

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial - PubMed

Chinese National Key Research and Development Program and Beijing Science and Technology Program.

pubmed.ncbi.nlm.nih.gov

Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD-based protein subunit vaccine (ZF2001) against COVID-19 in adults: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials - PubMed

For the Chinese translation of the abstract see Supplementary Materials section.

pubmed.ncbi.nlm.nih.gov

They were hit first. Making an inactivated virus vaccine was the safest bet that delivered results right away. Now they are considering other options.

OK, but where are they going to trial their other options? Presumably not in China, where there is no virus.

 

[Somewhereinba]

Let's be honest here the Chinese vaccines are shit. Poorer countries like Argentina and Brazil have no choice to use them because the bigger players do not trust their ability to pay and they don't have the resources to produce their own.

 

[camberiu]

Let's be honest here the Chinese vaccines are shit. Poorer countries like Argentina and Brazil have no choice to use them because the bigger players do not trust their ability to pay and they don't have the resources to produce their own.

Well, you can use AstroZeneca, a marvel of British biotechnology that causes blood clots.

 

[jeff1234]

China admits to ineffective vaccines, looks to foreign options

The Associated Press reports the director of the China Centers for Disease Control, Gao Fu, said Chinese vaccines “don’t have very high protection rates.”

China admits to ineffective vaccines, looks to other options

China's admission comes as an Oregon congressman pushes for effective vaccine formulas be shared to more quickly to end the coronavirus pandemic.

www.kgw.com

 

[antipodean]

OK, but where are they going to trial their other options? Presumably not in China, where there is no virus.

China aims to vaccinate entire city in 5 days after outbreak

A Chinese border city hit by a fresh outbreak of COVID-19 has begun a five-day drive to vaccinate its entire population of 300,000 people.

apnews.com

I don't see that it is possible to say a country the size and nature of China has "no" virus - otherwise this kind of news would not happen.
If China are saying they may need to give people a third shot to get optimal levels of protection, how the heck is that going to work in a region where countries like Argentine struggle to get even one shot into people's arm? Both time and money are slipping away.

What is missing from this discussion is still the "new" factor of key variants spreading in this region. All COVID vaccines have only been tested for a matter of months, not years, and mostly on strains that did not exist when they were deemed safe and X% effective. New studies on new variants take time and numbers even if there are a handful of "preliminary" studies. In Brazil Butantan found Sinovac only 73% effective against avoiding mild-severe illness - meaning it would not offer health systems as much protection as say Pfizer, Sputnik or Astrozenaca since 27% of those vaccinated and then infected may still require hospitalisation to avoid death (based on the evolution of facts to date.) Now doubts around Sinopharm's effectiveness against avoiding serious illness in Peru also need to be examined. Not even Sputnik V is free from this kind of issue nor any of the western counterparts. The looming doubt in the background to remain conscious of is that some coronaviruses just don't work with vaccines (e.g. common cold/ rhinovirus) and others (e.g. influenza) require new versions, and thus big logistics (e.g. time and money) ever year due to speed of mutation.

On the other hand, so far the only countries to have demonstrated a big downturn in cases, possibly due to having achieved massive vaccination levels of either first or second doses, are countries like UK, USA, Israel and UAE who mainly used Pfizer or AstraZeneca. However seasonality may still be a factor as people spend more time outdoors again - at the moment we just don't know for certain until their numbers pass the test of time. In the meantime the virus continues to mutate unevenly around the world.

 

[Somewhereinba]

Well, you can use AstroZeneca, a marvel of British biotechnology that causes blood clots.

In what % of patients - the purpose is the benefits far outweigh the extremely small negatives? Do you think the Chinese vaccine has well documented side effects studied?