It has long been known in the inner circles, and rumoured heavily in the outer circles the CFK is bipolar. The englishman who used to own 0800vino has it on authority of one of her personal doctors that he has been called various times to Olivos while she was in the grips of a mania. Now, okay, maybe mental illness shouldn't limit ones aspirations, but in a time of crisis the stress of the situation can certainly lead to some issues. All we need is for CFK to decide that now is the moment her meds are making her line of thought too cloudy and she decides to go off them. She's disappeared from the public eye for long periods during her term in office and the rumour has always been that it was for a readjustment of meds. Besides the potential bipolar condition she's also obviously got the dose of narcissism so common amongst leaders, political and otherwise. In this moment where delicate negotiation should be the path, her narcissism and (rumoured) mental health issues could truly bring down the whole government.
Let's face it, she's been off keel since Nestor's passing if not before, a worsening economic/political situation is just piling on the stress -- even the most self-controlled leaders would be losing it at this point. She only listens to a very few as well, you go against her -- or give her reason to suspect you are operating against her -- and you're going to be forced out.*
* see: Lousteau, Campos, Anibal Fernandez, Guillermo Moreno (though what a sweet deal he got, Ambassador to Italy, salary in Euros, he got the most gracious departure), Ocana (she was moved posts, was it her that got the weird transfer from Minister of Health to something with the Army?), Martin Redrado, y obvio Cobos. Scioli has been kept on the fence for ages, Sergio Massa used to be kirchnerista, now is running against and apparently has endless pits of money to campaign because he's unavoidable and we still have a long ways to go... and supposedly Kapitanich is on his way out as well.